Period Pain & Endometriosis

2021 Frontiers in Medicine

Adding acupuncture to conventional therapy may decrease the subsequent endometriosis risk in female rheumatoid arthritis patients.

Between 1998 and 2010, female subjects with RA were recruited from a nationwide database (5,736 patients; age ≥20 years). Enrolled patients included 2,407 acupuncture users and 2,407 nonusers randomly selected using propensity scores. The occurrence of endometriosis was recorded through the end of 2012. Cox proportional hazards regression was used to estimate the adjusted hazard ratio (HR) associated with acupuncture use.

Results: During the follow-up period, 35 acupuncture users and 94 non-users developed endometriosis, with incidence rates of 2.36 and 4.91 per 1,000 person-years, respectively. Acupuncture use was associated with a 55% lower endometriosis risk. Those who received high intensity acupuncture (≥15 packages) had the greatest benefit.

The results of multivariable analysis demonstrated that the use of acupuncture was related to a significantly reduced risk of endometriosis. In the subgroup analysis, the medium- to high-level intensity acupuncture use was found to possibly lessen the risk of having endometriosis for more than 70%. We discovered that the post-rheumatoid arthritis acupuncture use would significantly reduce the risk of endometriosis in a dose-dependent manner.

The Relationship of Acupuncture Use to the Endometriosis Risk in Females With Rheumatoid Arthritis: Real-World Evidence From Population-Based Health Claims Chen Wei-Jen, Livneh Hanoch, Hsu Chien-Hui, Hu Ying-To, Lai Ning-Sheng, Guo How-Ran, Tsai Tzung-Yi

2020 Evidence-Based Complementary and Alternative Medicine

The current evidence suggests that acupuncture and moxibustion is more effective than ibuprofen or Fenbid in the treatment of primary dysmenorrhoea.

This overview provided a comprehensive overview of the evidence on the effectiveness and safety of acupuncture and moxibustion for PD. Evidence of moderate quality suggested that acupuncture and moxibustion had a positive effect on indomethacin or Fenbid in treating PD. Low-quality evidence showed that compared to NSAIDs, acupuncture and moxibustion could relieve PD related pain with less adverse effects, which needs to be further researched. The adverse effects related to the acupuncture and moxibustion were mild, and they included dizziness, fainting, or minimal bleeding after acupuncture.

Effectiveness and Safety of Acupuncture and Moxibustion for Primary Dysmenorrhea: An Overview of Systematic Reviews and Meta-Analyses Jun Yang, Jun Xiong, Ting Yuan, Xue Wang, Yunfeng Jiang, Xiaohong Zhou, Kai Liao, Lingling Xu

2020 Journal of Maternal and Child Health

Acupuncture therapy can affect pain reduction in dysmenorrhea patients.

7 articles from South Korea, Taiwan, Spain, China, India, and Hong Kong were reviewed in this meta-analysis. This study showed that acupuncture therapy was -1.16 better in reducing pain in dysmenorrhea patients.

Effect of Acupuncture Therapy on Pain Reduction in Dysmenorrhea Patients: A Meta-Analysis Novitasari, E., Soemanto, R., & Prasetya, H.

2018 Medicine

Acupuncture might reduce menstrual pain and associated symptoms more effectively compared to no treatment or NSAIDs.

The results of this study suggest that acupuncture might reduce menstrual pain and associated symptoms more effectively compared to no treatment or NSAIDs, and the efficacy could be maintained during a short-term follow-up period. Despite limitations due to the low quality and methodological restrictions of the included studies, acupuncture might be used as an effective and safe treatment for females with primary dysmenorrhea.

The efficacy and safety of acupuncture in women with primary dysmenorrhea: A systematic review and meta-analysis. Woo, H. L., Ji, H. R., Pak, Y. K., Lee, H., Heo, S. J., Lee, J. M., & Park, K. S.

2018 International Journal of Gynecology & Obstetrics

Acupuncture showed a significant benefit in pain reduction for women with endometriosis as compared with placebo.

The complementary interventions studied were acupuncture, exercise, electrotherapy, and yoga. All were inconclusive in affirming benefit, but demonstrated a positive trend in the treatment of symptoms of endometriosis. Meta-analysis of acupuncture showed a significant benefit in pain reduction as compared with placebo.

Numerous complementary treatments have been used to alleviate the symptoms of endometriosis, but only acupuncture has demonstrated a significant improvement in outcomes.

Systematic review and meta-analysis of complementary treatments for women with symptomatic endometriosis Mira, T.A., Buen, M.M., Borges, M.G., Yela, D.A. and Benetti-Pinto, C.L.

2018 Reproductive Health

Traditional Chinese medicine that is often used for infertility treatment has shown successful results in controlling the recurrence of endometriosis following surgery thereby providing symptomatic pain relief and improving Health Related Quality of Life.

Traditional Chinese medicine is used in Chinese patients to control the recurrence of endometriosis following surgery, provide symptomatic pain relief, and improve Health Related Quality of Life (HRQoL). It is also often used to treat infertility.

Though several treatment regimens are available for the management of patients with endometrial lesions, alternative strategies are used in China. In conclusion, although Western medicine has been studied and validated more extensively for the treatment of endometriosis, both TCM and Western medicine are used equally in the treatment of endometriosis in Chinese women.

A review of the risk factors, genetics and treatment of endometriosis in Chinese women: a comparative update Dai, Y., Li, X., Shi, J. et al.

2017 PLOS One

The current literature suggests that acupuncture reduces endometriosis-related pain and serum CA-125 levels, regardless of the control intervention used.

Of the 10 studies included, only one pilot study used a placebo control and assessed blinding; the rest used various controls (medications and herbs), which were impossible to blind. The sample sizes were small in all studies, ranging from 8 to 36 patients per arm. The mean difference (MD) in pain reduction (pre- minus post-interventional pain level—measured on a 0–10-point scale) between the acupuncture and control groups was 1.36. Acupuncture had a positive effect on peripheral blood CA-125 levels, as compared with the control groups. Similarly, the effect of acupuncture on clinical effective rate was positive, as compared with the control groups.

Effects of acupuncture for the treatment of endometriosis-related pain: A systematic review and meta-analysis Yang Xu , Wenli Zhao , Te Li, Ye Zhao, Huaien Bu , Shilin Song

2017 BMC Complementary Medicine and Therapies

Acupoint-stimulation can relieve pain effectively in the treatment of primary dysmenorrhea and offers advantages compared with treatment by NSAIDs.

The current evidence reveals that acupoint-stimulation in the treatment of primary dysmenorrhea has some obvious advantages compared with treatment by NSAIDs. The advantages are that acupoint-stimulation can alleviate the symptoms of dysmenorrhoea, reduce the level of peripheral blood PGF2α and has fewer side effect, so it can be used to treat primary dysmenorrhea patients, especially individuals with NSAIDs contraindication.

Effects of acupoint-stimulation for the treatment of primary dysmenorrhoea compared with NSAIDs: a systematic review and meta-analysis of 19 RCTs Xu, Y., Zhao, W., Li, T. et al.

2017 Evidence-Based Complementary and Alternative Medicine

Electroacupuncture can provide considerable immediate analgesia effect for primary dysmenorrhea.

Our findings indicated that EA at SP6 can provide considerable immediate analgesic effect for primary dysmenorrhea and its immediate effect of pain relieving seems to be superior to control interventions. Moreover, there was greater prevalence of curative rate in the EA treatment group compared with the pharmacological treatments after a course of treatment. These results appear to be encouraging, but it should be considered at the same time that they are based on relatively low number of trials and relatively poor methodological quality of the primary studies. Hence, future research should be designed strictly and comprehensively to provide unbiased evidence about the efficacy of EA in the treatment of PD.

Electroacupuncture is Beneficial for Primary Dysmenorrhea: The Evidence from Meta-Analysis of Randomized Controlled Trials Si-yi Yu, Zheng-tao Lv, Qing Zhang, Sha Yang, Xi Wu, You-ping Hu, Fang Zeng, Fan-rong Liang, Jie Yang

2015 Journal of Acupuncture and Meridian Studies

Acupressure showed evidence of pain relief while acupuncture improved both the mental and the physical components of quality of life associated with primary dysmenorrhea.

This study involved three reviewers who dependently and independently performed study selection, quality assessment, and data extraction and management. Several interventions indicated statistical significance. Insights into the efficacies of the interventions were identified in correlation to themselves and with one another. The systematic review highlighted promising evidence in the form of studies done to establish the effectiveness of acupuncture and acupressure in the management of primary dysmenorrhea. However, the results were limited and had methodological flaws. The review and the meta-analysis indicated that acupressure significantly reduced the pain associated with primary dysmenorrhea and that acupuncture improved both the physical and the mental components of quality of life. The magnitude of these effects may or may not be clinically worthwhile, but as the costs and the risks of these interventions is low, these results may be clinically useful.

As Acupressure Decreases Pain, Acupuncture May Improve Some Aspects of Quality of Life for Women with Primary Dysmenorrhea: A Systematic Review with Meta-Analysis Abaraogu UO, Tabansi-Ochuogu CS

2013 Evidence-Based Complementary and Alternative Medicine

Our findings suggest that acupressure at the SP6 acupoint may provide more effective pain relief than that of control treatment.

This is the first systematic review to evaluate the effectiveness of acupuncture or acupressure at the SP6 acupoint for relieving pain associated with primary dysmenorrhea. Our findings suggest that acupuncture at the SP6 acupoint may not be more effective than acupuncture at an unrelated (GB39) acupoint for the relief of dysmenorrhea-associated pain (assessed using a VAS). In contrast, our findings suggest that acupressure at the SP6 acupoint may provide more effective relief from dysmenorrhea-associated pain than control interventions.

Clearly, there is a need for high-quality, randomized controlled trials to clarify the effectiveness of acupuncture/acupressure at the SP6 acupoint for the treatment of pain resulting from primary dysmenorrhea.

Acupuncture or Acupressure at the Sanyinjiao (SP6) Acupoint for the Treatment of Primary Dysmenorrhea: A Meta-Analysis Ma-Na Chen, Li-Wei Chien, Chi-Feng Liu